Your browser doesn't support javascript.
loading
Loss of FAT Atypical Cadherin 4 Expression Is Associated with High Pathologic T Stage in Radically Resected Gastric Cancer
Journal of Gastric Cancer ; : 39-45, 2015.
Artículo en Inglés | WPRIM | ID: wpr-176691
ABSTRACT

PURPOSE:

Recent studies have revealed recurrent alterations in the cell adhesion gene FAT4, a candidate tumor suppressor gene, in cancer. FAT atypical cadherin 4 (FAT4) is a transmembrane receptor involved in the Hippo signaling pathway, which is involved in the control of organ size. Here, we investigated the loss of FAT4 expression and its association with clinicopathological risk factors in gastric cancer. MATERIALS AND

METHODS:

We assessed the expression of FAT4 by using immunohistochemistry on three tissue microarrays containing samples from 136 gastric cancer cases, radically resected in the Soonchunhyang University Cheonan Hospital between July 2006 and June 2008. Cytoplasmic immunoexpression of FAT4 was semi-quantitatively scored using the H-score system. An H-score of > or =10 was considered positive for FAT4 expression.

RESULTS:

Variable cytoplasmic expressions of FAT4 were observed in gastric cancers, with 33 cases (24.3%) showing loss of expression (H-score or =10, 36.4% vs. 16.5%, P=0.015), high pathologic T stage (P=0.015), high tumor-node-metastasis stage (P=0.017), and reduced disease-free survival time (H-score or =10, mean survival 62.7+/-7.3 months vs. 79.1+/-3.1 months, P=0.025). However, no association was found between the loss of FAT4 expression and tumor size, gross type, histologic subtype, Lauren classification, lymphovascular invasion, or overall survival.

CONCLUSIONS:

Loss of FAT4 expression appears to be associated with invasiveness in gastric cancer.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tamaño de los Órganos / Neoplasias Gástricas / Inmunohistoquímica / Adhesión Celular / Factores de Riesgo / Genes Supresores de Tumor / Clasificación / Supervivencia sin Enfermedad / Citoplasma Tipo de estudio: Estudio de etiología / Factores de riesgo Idioma: Inglés Revista: Journal of Gastric Cancer Año: 2015 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tamaño de los Órganos / Neoplasias Gástricas / Inmunohistoquímica / Adhesión Celular / Factores de Riesgo / Genes Supresores de Tumor / Clasificación / Supervivencia sin Enfermedad / Citoplasma Tipo de estudio: Estudio de etiología / Factores de riesgo Idioma: Inglés Revista: Journal of Gastric Cancer Año: 2015 Tipo del documento: Artículo