Astroblastoma in a Young Female Patient: A Case Report and Literature Review of Clinicopathological, Radiological and Prognostic Characteristics and Current Treatment Strategies
Brain Tumor Research and Treatment
;
: 120-126, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-176892
ABSTRACT
Astroblastoma is an uncommon glial tumor with predominant manifestation in the young age. Herein, we report a case of 18-year-old astroblastoma female patient who presented with history of two months headache. Magnetic resonance imaging (MRI) of the brain demonstrated well circumscribed, intra-axial abnormal signal intensity lesion (size=5×4 cm²) in the right parieto-occipital region of the brain. The patient underwent complete surgical resection of the gross tumor, as confirmed by an early post-surgical MRI (i.e., within 24 hours of surgery). Histopathological examination revealed neoplastic lesion exhibiting perivascular pseudo-rosettes with centrally hyalinized blood vessel and focal nuclear pleomorphism. Immunohistochemistry staining illustrated reactivity for glial fibrillary acidic protein and integrase interactor 1 (INI-1). These features rendered the diagnosis of astroblastoma. A comprehensive review of the current literature to summarize the clinicopathological and radiological characteristics, prognostic factors and current treatment strategies of astroblastomas is also presented. Our study would expand the pool of this uncommon tumor towards its better understanding and optimal treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vasos Sanguíneos
/
Encéfalo
/
Neoplasias Encefálicas
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Inmunohistoquímica
/
Imagen por Resonancia Magnética
/
Neoplasias Neuroepiteliales
/
Integrasas
/
Craneotomía
/
Diagnóstico
/
Proteína Ácida Fibrilar de la Glía
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Adolescente
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Brain Tumor Research and Treatment
Año:
2017
Tipo del documento:
Artículo
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