Your browser doesn't support javascript.
loading
QS-21 enhances the early antibody response to oil adjuvant foot-and-mouth disease vaccine in cattle
Clinical and Experimental Vaccine Research ; : 138-147, 2016.
Artículo en Inglés | WPRIM | ID: wpr-176939
ABSTRACT

PURPOSE:

One of the most important tools against foot-and-mouth disease, a highly contagious and variable viral disease of cloven-hoofed animals, is vaccination. However, the effectiveness of foot-and-mouth disease vaccines on slowing the spread of the disease is questionable. In contrast, high potency vaccines providing early protection may solve issues with the spread of the disease, escaping mutants, and persistency. To increase the potency of the vaccine, additives such as saponin and aluminium hydroxide are used. However, the use of saponin with an oil adjuvant is not common and is sometimes linked to toxicity. QS-21, which is less toxic than Quil A, has been presented as an alternative for use with saponin. In this study, the addition of QS-21 to a commercially available foot-and-mouth disease water-in-oil-in-water emulsion vaccine was evaluated in cattle. MATERIALS AND

METHODS:

After vaccination, serum samples were collected periodically over 3 months. Sera of the QS-21 and normal oil vaccine groups were compared via serum virus neutralization antibody titre and liquid phase blocking enzyme-linked immunosorbent assay antibody titre.

RESULTS:

The results showed that there was a significant early antibody increase in the QS-21 group.

CONCLUSION:

Strong early virus neutralizing antibody response will be useful for emergency or ring vaccinations against foot-and-mouth disease in target animals.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Saponinas / Naciones Unidas / Virosis / Ensayo de Inmunoadsorción Enzimática / Vacunas / Vacunación / Urgencias Médicas / Anticuerpos Neutralizantes / Fiebre Aftosa / Formación de Anticuerpos Límite: Animales Idioma: Inglés Revista: Clinical and Experimental Vaccine Research Año: 2016 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Saponinas / Naciones Unidas / Virosis / Ensayo de Inmunoadsorción Enzimática / Vacunas / Vacunación / Urgencias Médicas / Anticuerpos Neutralizantes / Fiebre Aftosa / Formación de Anticuerpos Límite: Animales Idioma: Inglés Revista: Clinical and Experimental Vaccine Research Año: 2016 Tipo del documento: Artículo