Effects of Polygalae Radix on Apomorphine-Induced Stereotyped Behaviors in Mice / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 1317-1324, 1998.
Artículo
en Coreano
| WPRIM
| ID: wpr-177020
ABSTRACT
OBJECTIVES:
This study was to investigate in vivo activities of Polygalae Radix, a natural plant including active components having affinities to central nervous system receptors, using an animal model for psychotic disorders in terms of behavioral psychopharmacology.METHODS:
The extracts of Polygalae Radix in two concentrations of 5.0mg/g and 0..5mg/g were administered to mice in order to explore the suppression of apomorphine-induced stereotyped behaviors visually and to compare with the effects of haloperidol and control. 10 mice were tested in each groups.RESULTS:
The capacities of suppressing the apomorphine-induced stereotyped behaviors were observed in decreasing order of haloperidol, Polygalae Radix 5.0mg/g, Polygalae Radix 0..5mg/g and control. The extracts of Polygalae Radix in both concentrations suppressed apomorphine- induced stereotyped behaviors significantly, and Polygalae Radix 5.0mg/g was as potent as haloperidol.CONCLUSION:
This suggests that Polygalae Radix contain some effective ingredients to influence the central dopamine pathway in vivo. The identification of the chemical structures and the exploration of the biochemical and pharmacological characteristics of active components are to be required through further studies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plantas
/
Psicofarmacología
/
Trastornos Psicóticos
/
Conducta Estereotipada
/
Apomorfina
/
Dopamina
/
Sistema Nervioso Central
/
Modelos Animales
/
Polygala
/
Haloperidol
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Año:
1998
Tipo del documento:
Artículo
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