Regulation of NFATc1 in Osteoclast Differentiation
Journal of Bone Metabolism
;
: 233-241, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-177280
ABSTRACT
Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL). Activation of transcription factors such as microphthalmia transcription factor (MITF), c-Fos, NF-kappaB, and nuclear factor-activated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation. In particular, NFATc1 plays the role of a master transcription regulator of osteoclast differentiation. To date, several mechanisms, including transcription, methylation, ubiquitination, acetylation, and non-coding RNAs, have been shown to regulate expression and activation of NFATc1. In this review, we have summarized the various mechanisms that control NFATc1 regulation during osteoclast differentiation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoclastos
/
Acetilación
/
Factores de Transcripción
/
Matriz Ósea
/
Linfocitos T
/
Regulación de la Expresión Génica
/
Microftalmía
/
Citocinas
/
Factor Estimulante de Colonias de Macrófagos
/
FN-kappa B
Idioma:
Inglés
Revista:
Journal of Bone Metabolism
Año:
2014
Tipo del documento:
Artículo
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