The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder
Psychiatry Investigation
;
: 243-250, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-177400
ABSTRACT
The cognitive impairment and neuroanatomical changes that takes place among patients with bipolar disorder (BD) patients has been well described. Recent data suggest that changes in neuroplasticity, cell resilience and connectivity are the main neuropathological findings in BD. Data from differential lines of research converges to the brain-derived neurotrophic factor (BDNF) as an important contributor to the neuroplasticity changes described among BD patients. BDNF serum levels have been shown to be decreased in depressive and manic episodes, returning to normal levels in euthymia. BDNF has also been shown to decrease as the disorder progresses. Moreover, factors that negatively influence the course of BD, such as life stress and trauma have been shown to be associated with a decrease in BDNF serum levels. These findings suggest that BDNF plays a central role in the progression of BD. The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the potential use of serum BDNF as a biomarker in BD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estrés Psicológico
/
Trastorno Bipolar
/
Oftalmoplejía
/
Factor Neurotrófico Derivado del Encéfalo
/
Enfermedades Mitocondriales
/
Hipogonadismo
/
Factores de Crecimiento Nervioso
/
Plasticidad Neuronal
Límite:
Humanos
Idioma:
Inglés
Revista:
Psychiatry Investigation
Año:
2010
Tipo del documento:
Artículo
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