Overexpression of Periostin Protein in Non-Small Cell Lung Carcinoma is Not Related with Clinical Prognostic Significance / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 132-139, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-177725
ABSTRACT
BACKGROUND:
Periostin is preferentially expressed in periosteum, indicating a potential role in bone formation. Recently, there have been emerging controversies about its role in invasion and metastasis of human malignancies. We attempted to determine the clinicopathological significance of periostin expression in non-small cell lung carcinoma (NSCLC).METHODS:
Immunohistochemical staining of periostin protein from 91 cases of NSCLCs was performed using tissue microarray blocks. The results were correlated with clinicopathological parameters.RESULTS:
Positive reaction to periostin was predominantly noted in the tumor stroma. The strongest reaction presented as a band-like pattern just around the tumor nests. Non-neoplastic lung tissue and most in-situ carcinomas did not show a positive reaction in their stroma. With respect to tumor differentiation, moderate to poor differentiated tumors (47/77) revealed even higher periostin expression than the well-differentiated ones (4/14) (p=0.024). High periostin expression was positively correlated with E-cadherin and p53 expression, but was not related with patient age, sex, tumor type, PCNA index, b-catenin, cyclin D1, pTNM-T, pTNM-N, stage, and patient survival (p>0.05).CONCLUSION:
These results suggest that periostin might play a role during the biological progression of NSCLC, but may not be related to the clinical prognostic parameters.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteogénesis
/
Periostio
/
Cadherinas
/
Genes p53
/
Carcinoma de Pulmón de Células no Pequeñas
/
Antígeno Nuclear de Célula en Proliferación
/
Ciclina D1
/
Pulmón
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Tuberculosis and Respiratory Diseases
Año:
2012
Tipo del documento:
Artículo
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