The Role of Heat Shock Response in Insulin Resistance and Diabetes
Diabetes & Metabolism Journal
;
: 100-106, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-17798
ABSTRACT
The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators found that physical medicine using simultaneous stimulation of heat with mild electric current activates heat shock response, thereby reducing visceral adiposity, insulin resistance, chronic inflammation and improving glucose homeostasis in mice models of T2DM, as well as in humans with MS or T2DM. This combination therapy exerts novel action on insulin signaling, beta-cell protection and body compositions, and may provide a new therapeutic alternative in diabetic treatment strategy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Medicina Física y Rehabilitación
/
Composición Corporal
/
Resistencia a la Insulina
/
Respuesta al Choque Térmico
/
Citoprotección
/
Diabetes Mellitus
/
Diabetes Mellitus Tipo 2
/
Adiposidad
/
Glucosa
/
Calor
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Diabetes & Metabolism Journal
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS