Effect of Pioglitazone on Excitotoxic Neuronal Damage in the Mouse Hippocampus
Biomolecules & Therapeutics
;
: 261-267, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-178036
ABSTRACT
Pioglitazone (PGZ), a synthetic peroxisome proliferator-activated receptor gamma agonist, is known to regulate inflammatory process and to have neuroprotective effects against neurological disorders. In the present study, we examined the effects of 30 mg/kg PGZ on excitotoxic neuronal damage and glial activation in the mouse hippocampus following intracerebroventricular injection of kainic acid (KA). PGZ treatment significantly reduced seizure-like behavior. PGZ had the neuroprotective effect against KA-induced neuronal damage and attenuated the activations of astrocytes and microglia in the hippocampal CA3 region. In addition, MPO and NFkappaB immunoreactivities in the glial cells were also decreased in the PGZ-treated group. These results indicate that PGZ had anticonvulsant and neuroprotective effects against KA-induced excitotocix injury, and that neuroprotective effect of PGZ might be due to the attenuation of KA-induced activation in astrocytes and microglia as well as KA-induced increases in MPO and NFkappaB.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neuroglía
/
Astrocitos
/
Microglía
/
Fármacos Neuroprotectores
/
PPAR gamma
/
Región CA3 Hipocampal
/
Hipocampo
/
Ácido Kaínico
/
Enfermedades del Sistema Nervioso
/
Neuronas
Límite:
Animales
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2015
Tipo del documento:
Artículo
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