Molecular Epidemiology of Hepatitis A Virus in the South-East Area of Gyeonggi-do in Korea
Yonsei Medical Journal
;
: 512-516, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-178613
ABSTRACT
PURPOSE:
Hepatitis A virus (HAV) has been a leading cause of acute hepatitis in Korea. The reported genotypes of acute hepatitis A in Korea are the subgenotype IA and IB. The aim of the present study is to investigate HAV genotypes in the south-east area of Gyeonggi-do in Korea. MATERIALS ANDMETHODS:
From June 2004 to June 2006, 46 acute hepatitis A patients were enrolled prospectively. All had sporadic acute hepatitis A patients. All suspected cases of acute hepatitis A were tested for IgM anti-HAV antibodies. We sequenced 168 bp of nucleotides of the putative VP1/P2A junction and determined the HAV genotype with reverse transcriptase polymerase chain reaction. The clinical and laboratory results of all patients were recorded.RESULTS:
HAV-ribonucleic acid (RNA) was detected in 41 samples out of 46 samples. Among the 41 samples, 25 (60%) were shown to have subgenotype IIIA and the other 16 (40%) were subgenotype IA. Several amino acid substitutions were found.CONCLUSION:
In these HAV sporadic cases, IIIA and IA were identified, and this may reflect co-circulation of various genotypes in Korea. This study provides valuable new data on the genetic distribution of HAV and important information to help design appropriate public health measures.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Filogenia
/
Virus de la Hepatitis A Humana
/
Epidemiología Molecular
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Genotipo
/
Hepatitis A
/
Corea (Geográfico)
Tipo de estudio:
Estudio de tamizaje
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS