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Association of preterm birth with IFN-gamma, IL-10, and CYP 1A1 gene in Korean women / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology ; : 608-615, 2010.
Artículo en Coreano | WPRIM | ID: wpr-179072
ABSTRACT

OBJECTIVE:

To investigate the association between preterm birth and cytokine genes (IFN-gamma, interleukin (IL)-10) in intrauterine infection and enzyme gene (CYP1A1) in oxidative stress response.

METHODS:

This study involved a case-control study conducted at Ewha Womans University Hospital in Seoul, Korea. Subjects with preterm deliveries ( or =37 weeks of gestation) were selected from gravidas who had undergone prenatal examinations in the hospital and were followed until infant delivery. The weight, height, and blood samples of each participants were obtained according to standard protocols. We included subjects who gave birth to a singleton infant and had a gestational age between 24 and 42 weeks. Mutiple births, stillbirths, and congenital anomalies were excluded. Finally, 164 gravidas with preterm births and 305 normal controls with term deliveries were enrolled in the present study.

RESULTS:

Preterm delivery group and term delivery group had significant difference in gestational age and neonatal body weight (P0.05).

CONCLUSION:

In this study, IFN-gamma (874A/T), IL-10 (1082A/G), IL-10 (819C/T), IL-10 (592A/C) and CYP1A1 (T6235C), CYP1A1 (Ile462val [A/G]) genes had no significant association with preterm birth.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Peso Corporal / Estudios de Casos y Controles / Edad Gestacional / Interleucinas / Interleucina-10 / Estrés Oxidativo / Citocromo P-450 CYP1A1 / Parto / Nacimiento Prematuro / Mortinato Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Femenino / Humanos / Lactante País/Región como asunto: Asia Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Peso Corporal / Estudios de Casos y Controles / Edad Gestacional / Interleucinas / Interleucina-10 / Estrés Oxidativo / Citocromo P-450 CYP1A1 / Parto / Nacimiento Prematuro / Mortinato Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Femenino / Humanos / Lactante País/Región como asunto: Asia Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2010 Tipo del documento: Artículo