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Prognostic Value of Leptin in Terminally Ill Cancer Patients / 한국호스피스완화의료학회지
Korean Journal of Hospice and Palliative Care ; : 99-107, 2012.
Artículo en Coreano | WPRIM | ID: wpr-179598
ABSTRACT

PURPOSE:

Most terminally ill cancer patients die from cancer anorexia-cachexia syndrome. This study evaluated a prognostic role of plasma leptin levels in terminally ill cancer patients.

METHODS:

This study enrolled 69 terminally ill cancer patients who were aged above 20 years old from July 2009 to July 2010. For univariate analysis, an association between leptin levels and patient's characteristics or other variables was examined using Spearman's correlation analysis, Wilcoxon's rank-sum test or Kruskal-Wallis test, as appropriately. For multivariable analysis, Cox's proportional hazard regression model was used to evaluate a clinical significance of plasma leptin levels as a prognostic factor and to determine factors which affect the risk of death in terminally ill cancer patients.

RESULTS:

A statistically significant positive correlation between plasma leptin levels and survival time was found. Univariate Cox's proportional hazard regression analyses also showed a moderately significant association between plasma leptin levels and survival time. However, after adjusting variables for sex, white blood cell counts, total bilirubin, AST, ALT, albumin and CRP levels, plasma leptin levels were not significantly associated with survival time.

CONCLUSION:

No significant association was found between plasma leptin levels and survival time in terminally ill cancer patients. However, this study suggested a prognostic value of plasma leptin levels in gastrointestinal cancer patients.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Bilirrubina / Tasa de Supervivencia / Esperanza de Vida / Cuidados Paliativos al Final de la Vida / Enfermo Terminal / Leptina / Neoplasias Gastrointestinales / Recuento de Leucocitos Tipo de estudio: Estudio pronóstico Límite: Anciano / Humanos Idioma: Coreano Revista: Korean Journal of Hospice and Palliative Care Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Bilirrubina / Tasa de Supervivencia / Esperanza de Vida / Cuidados Paliativos al Final de la Vida / Enfermo Terminal / Leptina / Neoplasias Gastrointestinales / Recuento de Leucocitos Tipo de estudio: Estudio pronóstico Límite: Anciano / Humanos Idioma: Coreano Revista: Korean Journal of Hospice and Palliative Care Año: 2012 Tipo del documento: Artículo