p21WAF1/CIP1 Codon 31 Polymorphism in Korean Women: Association with Cervical Cancer Susceptibility and Prognosis / 대한암학회지
Journal of the Korean Cancer Association
;
: 1050-1058, 2000.
Artículo
en Coreano
| WPRIM
| ID: wpr-179727
ABSTRACT
PURPOSE:
The aim of this study was to determine whether certain genotype of p21WAF1/Cip1 might be associated with risk of cervical cancer in Korean women. MATERIALS ANDMETHODS:
We used the specimens derived from cervical cancer (n=111) composed of two histologic groups; SCCA (n=67) and adenocarcinoma (n=44), CIN III (n=101) and controls (n=98). For the determination of p21WAF1/Cip1 polymorphism, DNA was examined by PCR-RFLP using BsmAI. We compared the distribution of p21WAF1/Cip1 genotype of Korean women with that of other ethnic groups and analyzed the distribution of invasive cancer, CIN III and controls.RESULTS:
The genotype frequency of controls was different from that of Caucasian and Chinese (p0.05). A significant increase of Ser/Ser genotype was found in adenocarcinoma patients with high-risk HPV compared with the controls (p=0.009). The OR was 3.59, 95% CI=1.55~8.31, when comparing that group with controls. However, we could not find differences of prognosis.CONCLUSION:
We found that codon 31 Ser/Ser homozygote of the p21WAF1/Cip1 would be a risk factor for the adenocarcinoma of cervix associated with high-risk HPV in Korean women.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Codón
/
ADN
/
Adenocarcinoma
/
Etnicidad
/
Neoplasias del Cuello Uterino
/
Cuello del Útero
/
Factores de Riesgo
/
Pueblo Asiatico
/
Genotipo
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Cancer Association
Año:
2000
Tipo del documento:
Artículo
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