Erythropoietin and autoimmune neuroinflammation: lessons from experimental autoimmune encephalomyelitis and experimental autoimmune neuritis / 대한해부학회지
Anatomy & Cell Biology
; : 215-220, 2012.
Article
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| ID: wpr-179888
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WPRO
ABSTRACT
Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis. These secondary functions of EPO are integral to tissue protection following hypoxic injury, ischemia-reperfusion injury, and spinal cord injury in the central nervous system. This review focuses on experimental evidence documenting the neuroprotective effects of EPO in organ-specific autoimmune nervous system disorders such as experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN). In addition, the immunomodulatory role of EPO in the pathogenesis of EAE and EAN animal models of human multiple sclerosis and Guillain-Barre syndrome, respectively, will be discussed.
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WPRIM
Asunto principal:
Enfermedades Autoinmunes
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Traumatismos de la Médula Espinal
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Daño por Reperfusión
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Sistema Nervioso Central
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Eritropoyetina
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Fármacos Neuroprotectores
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Citoprotección
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Síndrome de Guillain-Barré
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Modelos Animales
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Encefalomielitis
Límite:
Humans
Idioma:
En
Revista:
Anatomy & Cell Biology
Año:
2012
Tipo del documento:
Article