Toxicity of Benzalkonium Chloride on Corneal Endothelium of Rabbits
Journal of the Korean Ophthalmological Society
;
: 1155-1161, 1995.
Artículo
en Coreano
| WPRIM
| ID: wpr-180160
ABSTRACT
An experimental study was performed on 16 rabbits to evaluate the toxicity of benzalkonium chloride(BAK) on the corneal endothelium. Each rabbit received two drops of 0.01% BAK in the right eye and BSS in the left eye as control. The rabbits were divided into 4 groups instillation of BAK 20 times at 6-minute intervals in normal cornea(group 1), instillation of BAK 40 times at 3-minute intervals in normal cornea (group 2), instillation of BAK 20 times at 6-minute intervals in de-epithelized condition with the size of 6mm diameter(group 3) and instillation of BAK 40 times at 3-minute intervals in deepithelized cornea(group 4). After the last instillation of BAK, histopathologic examination was performed with electron microscope. Group 1 showed nearly normal corneal endothelial findings, but group 2, 3 and 4 showed enlarged rough endoplasmic reticulum, partially distrupted Goigi apparatus and mitochodria, the presence of vacuoles and phagosomes. Group 4 showed severe destruction of subcellular structures. The results of this study indicate that an exaggerated use of topical drug containing 0.01% BAK may induce corneal endothelial damage, especially when the epithelium was already damaged.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vacuolas
/
Compuestos de Benzalconio
/
Fagosomas
/
Endotelio Corneal
/
Retículo Endoplásmico Rugoso
/
Córnea
/
Epitelio
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Año:
1995
Tipo del documento:
Artículo
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