Beneficial Effects of Thiazolidinediones on Diabetic Nephropathy in OLETF Rats
Yonsei Medical Journal
;
: 301-307, 2007.
Artículo
en Inglés
| WPRIM
| ID: wpr-180515
ABSTRACT
PURPOSE:
Diabetic nephropathy is the most serious of complications in diabetes mellitus. Thiazolidinedione (TZD) is thought to ameliorate diabetic nephropathy; however, the mechanism underlying this effect has not been elucidated. We hypothesized that the vascular endothelial growth factor (VEGF) participates in the pathogenesis of diabetic nephropathy and that TZD may be beneficial for the treatment of diabetic nephropathy because of the effect it has on VEGF. MATERIALS ANDMETHODS:
23 Otsuka- Long-Evans-Tokushima-Fatty (OLETF) rats and eight control Long-Evans-Tokushima-Otsuka (LETO) rats were divided into the following four groups LETO group, control OLETF group, pioglitazone treated group (10mg/kg/day), and rosiglitazone treated group (3mg/kg/day).RESULTS:
A progressive increase in urinary protein excretion was observed in the diabetic rats. Glomerular VEGF expression in the control OLETF rats was significantly higher than in the control LETO rats. However, there was a significant reduction in both the glomerular VEGF expression and the VEGF mRNA levels after treatment with pioglitazone and rosiglitazone. The twenty-four hour urine protein levels were significantly decreased in both groups of the treated OLETF rats.CONCLUSION:
These results suggest that TZD may have beneficial effects on diabetic nephropathy by reducing the VEGF expression.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ratas Long-Evans
/
Tiazolidinedionas
/
Factor A de Crecimiento Endotelial Vascular
/
Diabetes Mellitus Tipo 2
/
Nefropatías Diabéticas
/
Modelos Animales de Enfermedad
/
Hipoglucemiantes
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2007
Tipo del documento:
Artículo
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