Molecular-epidemiologic study on outbreak of colonization by extended spectrum beta-lactamase producing Klebsiella pneumoniae in neonatal intensive care unit / 소아과
Korean Journal of Pediatrics
;
: 150-156, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-180577
ABSTRACT
PURPOSE:
The aims of this study included assessment of molecular-epidemiologic features during an outbreak of colonization of extended spectrum beta-lactamase producing Klebsiella pneumoniae(ESBL-KPN) and re-evaluation of their colonized status one year later.METHODS:
Rectal swab cultures for ESBL-KPN from all hospitalized infants and newly admitted infants were obtained during the outbreak of colonization from July to December, 2000. The pattern of XbaI-digested chromosomal DNA of isolates were analyzed by pulsed-field gel electrophoresis. Weekly rectal swab cultures were obtained during the outbreak until patients were either discharged or decolonized. Patients discharged after being colonized had follow up stool cultures a year later.RESULTS:
A total of 80 patients(28.5 percent) were colonized. Of those, 53 whose pulsed-field gel electrophoresis(PFGE) was possible only once, were ESBL-KPN grouped into six cluster clones and 10 single clones28 patients(52.8 percent) were colonized with type A, the most common clone, followed by type B in 11 patients(20.8 percent). Of those 12 patients in whom serial PFGE was done more than twice, type A was predominant. Narrowed-down in strains occurred from types A, B, C, D and three single clones at initiation of the study into types A and type B after three months of strict infection control. Among 75 patients(93.7 percent) who were sent home after being colonized, 30 patients were re-called for stool cultures a year laterAll of them were decolonized.CONCLUSION:
This study demonstrates the importance of infection control as the diversity of ESBL-KPN strains could be narrowed into fewer strains. Colonization of ESBL-KPN could be reversed upon return to the community.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Beta-Lactamasas
/
ADN
/
Cuidado Intensivo Neonatal
/
Estudios de Seguimiento
/
Control de Infecciones
/
Electroforesis en Gel de Campo Pulsado
/
Células Clonales
/
Colon
/
Klebsiella
/
Klebsiella pneumoniae
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
/
Lactante
/
Recién Nacido
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Año:
2006
Tipo del documento:
Artículo
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