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Longevity of Antibodies to Live Orientia tsutsugamushi Inoculated in Sprague Dawley Rats
Journal of the Korean Society of Virology ; : 193-201, 1998.
Artículo en Inglés | WPRIM | ID: wpr-180696
ABSTRACT
In Sprague Dawley (SD) rats, antibodies against strains of Orinentia tsutsugamushi, Kato, Karp and Gilliam, were produced in order to investigate their longevity and cross-reactivities to their corresponding homologous and heterologous antigens. By immunofluorescence assay (IFA) of IgG and IgM, it was shown that the immunity to the homologous strains persisted at a higher level (longevity of at least 34 weeks with higher IFA titers). On the other hand, the immunity to the heterologous strains persisted at a lower level (longevity of 10 to 34 weeks with lower IFA titers). Since infection with one strain of O. tsutsugamushi does not preclude reinfection with other strains, understanding of the antigenic diversity of O. tsutsugamushi and duration of the immunity to both homologous and heterologous strain is very important in diagnosis of scrub typhus.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Orientia tsutsugamushi / Inmunoglobulina G / Inmunoglobulina M / Tifus por Ácaros / Variación Antigénica / Antígenos Heterófilos / Técnica del Anticuerpo Fluorescente / Ratas Sprague-Dawley / Diagnóstico / Mano Tipo de estudio: Estudio diagnóstico Límite: Animales Idioma: Inglés Revista: Journal of the Korean Society of Virology Año: 1998 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Orientia tsutsugamushi / Inmunoglobulina G / Inmunoglobulina M / Tifus por Ácaros / Variación Antigénica / Antígenos Heterófilos / Técnica del Anticuerpo Fluorescente / Ratas Sprague-Dawley / Diagnóstico / Mano Tipo de estudio: Estudio diagnóstico Límite: Animales Idioma: Inglés Revista: Journal of the Korean Society of Virology Año: 1998 Tipo del documento: Artículo