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Effects of Nitric Oxide Synthase Inhibitor on Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury
Journal of Korean Academy of Nursing ; : 520-527, 2011.
Artículo en Coreano | WPRIM | ID: wpr-180901
ABSTRACT

PURPOSE:

The purpose of this study was to examine effects of nitric oxide synthase (NOS) inhibitor on muscle weight and myofibrillar protein content of affected and unaffected hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury.

METHODS:

Neuropathic pain was induced by ligation and cutting of the left L5 spinal nerve. Adult male Sprague-Dawley rats were randomly assigned to one of two groups The NOSI group (n=19) had NOS inhibitor (L-NAME) injections daily for 14 days, and the Vehicle group (n=20) had vehicle injections daily for 14 days. Withdrawal threshold, body weight, food intake and activity were measured every day. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles were dissected from hindlimbs. Muscle weight and myofibrillar protein content of the dissected muscles were determined.

RESULTS:

The NOSI group showed significant increases as compared to the Vehicle group for body weight at 15 days, muscle weight and myofibrillar protein content of the unaffected soleus and gastrocnemius. The NOSI group demonstrated a higher pain threshold than the vehicle group.

CONCLUSION:

NOSI for 14 days attenuates unaffected soleus and gastrocnemius muscle atrophy in neuropathic pain model.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Peso Corporal / Atrofia Muscular / Ratas Sprague-Dawley / Fibras Musculares Esqueléticas / Óxido Nítrico Sintasa / NG-Nitroarginina Metil Éster / Modelos Animales de Enfermedad / Ingestión de Alimentos / Inhibidores Enzimáticos / Traumatismos de los Nervios Periféricos Límite: Animales Idioma: Coreano Revista: Journal of Korean Academy of Nursing Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Peso Corporal / Atrofia Muscular / Ratas Sprague-Dawley / Fibras Musculares Esqueléticas / Óxido Nítrico Sintasa / NG-Nitroarginina Metil Éster / Modelos Animales de Enfermedad / Ingestión de Alimentos / Inhibidores Enzimáticos / Traumatismos de los Nervios Periféricos Límite: Animales Idioma: Coreano Revista: Journal of Korean Academy of Nursing Año: 2011 Tipo del documento: Artículo