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KR-31831, a new synthetic anti-ischemic agent, inhibits in vivo and in vitro angiogenesis
Experimental & Molecular Medicine ; : 502-508, 2006.
Artículo en Inglés | WPRIM | ID: wpr-181049
ABSTRACT
Angiogenesis is considered to be an integral process to the growth and spread of solid tumors. Anti-angiogenesis therapy recently has been found to be one of the most promising anti-cancer therapeutic strategies. In this study, we provide several lines of evidences showing that KR-31831, a new benzopyran derivative, has anti-angiogenic activities. KR-31831 inhibited the proliferation, migration, invasion and tube formation of bovine aortic endothelial cells (BAECs), and suppressed the release of matrix metalloproteinase-2 (MMP-2) of BAECs. KR-31831 also inhibited in vivo angiogenesis in mouse Matrigel plug assay. Furthermore, the mRNA expressions of basic fibroblast growth factor (bFGF), fibroblast growth factor receptor-2 (FGFR-2), and vascular endothelial growth factor receptor-2 (VEGFR-2) were decreased by KR-31831. Taken together, these results suggest that KR-31831 acts as a novel angiogenesis inhibitor and might be useful for treating hypervascularized cancers.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Benzopiranos / Movimiento Celular / Células Cultivadas / Factor 2 de Crecimiento de Fibroblastos / Neovascularización Fisiológica / Metaloproteinasa 2 de la Matriz / Inhibidores de la Angiogénesis / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Células Endoteliales / Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Benzopiranos / Movimiento Celular / Células Cultivadas / Factor 2 de Crecimiento de Fibroblastos / Neovascularización Fisiológica / Metaloproteinasa 2 de la Matriz / Inhibidores de la Angiogénesis / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Células Endoteliales / Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2006 Tipo del documento: Artículo