A Study of Serum Lipids and Lipoproteins in Patients with Psoriasis / 대한피부과학회지

ABSTRACT

BACKGROUND: Previous studies have demonstrated that patients with psoriasis may have an increased risk of contacting a variety of noncutaneous diseases, including arterial and venous occlusive diseases. Changes in plasma lipid and lipoprotein composition in patients with psoriasis may be the reason for the increased risk of atherosclerosis in these patients. OBJECTIVE: This study was carried out to investigate the differences of serurn lipid, lipoprotein and apolipoprotein levels between the psoriasis patients and control groups and to suggest which are related with atherogenic risk in the psoriasis. METHODS: Serum lipid, lipoprotein and apolipoprotein levels were measured in 100 patient with psoriasis and in 30 healthy people. RESULTS: In the serum lipids study total cholesterol, TG, LDL-C and VLDL-C levels were lower and HDL-C level was higher in the psoriasis group than in the control group. Statistical significant differences were noticed in total cholesterol levels between the female psoriasis patients and the female control groups. In the serum lipoproteins study apolipoprotein B and lipoprotein (a) levels were higher and apolipoprotein A I level was lower in the psoriasis group than in the control group, and statistical significant differences of apolipoprotein B and lipoprotein (a) levels were noticed in the atherogenic risk group and severe psoriasis group compared with the control group. CONCLUSION: These findings suggest that the atherogenic risk in psoriasis is related with the high level of apolipoproteins especially apolipoprotein B, and is not related with serum lipid.