Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse
Experimental & Molecular Medicine
;
: 65-69, 2005.
Artículo
en Inglés
| WPRIM
| ID: wpr-18129
ABSTRACT
This study was conducted to determine if an oral squamous cell carcinoma alters mRNA expression of serotonin transporter (5-HTT) in the central nervous system. KB cell line derived from a human oral squamous cell carcinoma was inoculated into nude mice, and mRNA expression level of 5-HTT in the dorsal raphe nucleus (DRN) was examined by in situ hybridization when the tumor mass reached to -10% of total body weight. Plasma leptin levels were determined by radioimmunoassay method using a commercial kit. 5-HTT mRNA level was significantly decreased in the DRN of tumor bearing mice, compared to the age-matching non-tumor control. Plasma leptin level decreased concomitantly in tumor bearing mice. These results suggest that oral carcinoma may suppress 5-HTT gene expression in the central nervous system, perhaps in relation with decreased plasma leptin level.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas de Transporte de Membrana
/
Peso Corporal
/
ARN Mensajero
/
Neoplasias de la Boca
/
Radioinmunoensayo
/
Núcleos del Rafe
/
Glicoproteínas de Membrana
/
Carcinoma de Células Escamosas
/
Serotonina
/
Regulación Neoplásica de la Expresión Génica
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2005
Tipo del documento:
Artículo
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