Signaling Pathways in Osteoclast Differentiation / 전남의대학술지
Chonnam Medical Journal
;
: 12-17, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-181510
ABSTRACT
Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-kappaB ligand (RANKL). M-CSF and RANKL bind to their respective receptors c-Fms and RANK to stimulate osteoclast differentiation through regulation of delicate signaling systems. Here, we summarize the critical or essential signaling pathways for osteoclast differentiation including M-CSF-c-Fms signaling, RANKL-RANK signaling, and costimulatory signaling for RANK.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoclastos
/
Huesos
/
Matriz Ósea
/
Transducción de Señal
/
Citocinas
/
Factor Estimulante de Colonias de Macrófagos
/
Ligando RANK
Idioma:
Inglés
Revista:
Chonnam Medical Journal
Año:
2016
Tipo del documento:
Artículo
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