The effect of estrogen deficiency on rat pulpodentinal complex / 대한치과보존학회지
Journal of Korean Academy of Conservative Dentistry
;
: 402-408, 2005.
Artículo
en Inglés
| WPRIM
| ID: wpr-182040
ABSTRACT
The purpose of this study was to investigate the effects of estrogen deficiency on pulpodentinal complex of tooth in ovariectomized rats. Thirty female Sprague-Dawley rats, 10 weeks old, were used. Rats were grouped into two groups. One group (n = 15) was subjected to sham surgery (SHAM) and the other group (n = 15) was ovariectomized bilaterally (OVX). Animals were sacrificed 12 weeks later, and their mandibular molars and associated periodontal supporting tissues were dissected out, and fixed in 10% buffered formalin. For comparison of groups, immunostained for osteonectin. Histomorphometrical measurement of change of teeth was performed using an image analysis system and paired t-test was used and the level of significance for overall differences was set at p < 0.05. In immunostaining of osteonectin, they were significantly different from each other. The predentin thickness in OVX rats was wider than in SHAM rats. And in SHAM rats, osteonectin was more specifically stained in predentin areas than in OVX rats. These results indicate that estrogen deficiency increased the unmineralized predentin areas and decreased osteonectin content in pulpal tissues in rats. If our result is applicable to human studies, odotoblast is affected by estrogen deficiency.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Diente
/
Ovariectomía
/
Osteonectina
/
Ratas Sprague-Dawley
/
Estrógenos
/
Formaldehído
/
Diente Molar
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Korean Academy of Conservative Dentistry
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS