Clinicial Significance of Spontaneous Pneumomediastinum in Dermatomyositis/Polymyositis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 143-152, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-182266
ABSTRACT
OBJECTIVE:
Pneumomediastinum (PnM), a rare complication of dermatomyositis and polymyositis (DM/PM), is sporadic and has an unclear pathogenesis. PnM is almost always associated with interstitial lung disease (ILD), and is a poor prognostic factor in inflammatory myositis patients. We studied the prevalence of PnM in Korean DM/PM and its clinical significance.METHODS:
We retrospectively studied the medical records of 161 patients diagnosed with DM/PM meeting Bohan-Peter's criteria at Hanyang University Hospital for Rheumatic Diseases from 1995 to 2010. We collected following findings; demographic data, diagnosis, lung involvement, cause of death, and duration from diagnosis to death.RESULTS:
One hundred nineteen patients (73.9%) were DM and 42 patients (26.1%) were PM. Eighty three patients (51.6%) developed ILD at diagnosis or during follow up. Eighteen patients (11.2%) died because of ILD aggravation, infection, or malignancy. The mean duration from diagnosis to death was 11.5 months, with 10 patients (6.2%) dying from from ILD aggravation but none with spontaneous PnM. 6 patients (3.7%) presented with PnM, and it was associated with ILD worsening in all cases. PnM resolved with O2 inhalation, corticosteroids, and/or immunosuppressive agents after 11 weeks (mean) of therapy.CONCLUSION:
PnM is rare but associates with DM and aggravation of ILD. PnM does not usually cause fatalities and can be cured by appropriate therapy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Inhalación
/
Registros Médicos
/
Enfermedades Reumáticas
/
Prevalencia
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Causas de Muerte
/
Polimiositis
/
Corticoesteroides
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Año:
2010
Tipo del documento:
Artículo
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