ANCA Associated Vasculitis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
; : 108-132, 2010.
Article
en Ko
| WPRIM
| ID: wpr-182268
Biblioteca responsable:
WPRO
ABSTRACT
Primary antineutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAV) constitute a group of small vessel vasculitides that includes Wegener's granulomatosis, microscopic polyangiitis and Churg-Strauss syndrome. Recently, many in vitro and in vivo studies have highlighted the role of ANCA as the main pathophysiological factor in the development of AAV. Two remarkable studies on ANCA pathogenesis were recently reported. One study examined anti-lysosomal membrane protein-2, which supports the 'shared epitope' theory. The other examined the neutrophil extracellular trap that is released by neutrophils primed by ANCA. Each disease of AAV shows a broad spectrum of the clinical features and severities, which makes it difficult to diagnose and treat them. Considerable effort has been made in the past decades to improve the treatment outcomes, reduce the incidence of relapse and avoid drug toxicity. This review describes the current understanding of AAV along with a few Korean reports.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Recurrencia
/
Vasculitis
/
Síndrome de Churg-Strauss
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Granulomatosis con Poliangitis
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Incidencia
/
Anticuerpos Anticitoplasma de Neutrófilos
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Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
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Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos
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Poliangitis Microscópica
/
Glicosaminoglicanos
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Idioma:
Ko
Revista:
The Journal of the Korean Rheumatism Association
Año:
2010
Tipo del documento:
Article