TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
Journal of Korean Medical Science
;
: 1423-1428, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-183079
ABSTRACT
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR]=1.38, 95% confidence interval [CI]=1.05-1.81, P=0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Adenocarcinoma
/
Estudios de Casos y Controles
/
Regiones Promotoras Genéticas
/
Telómero
/
Telomerasa
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Estudios de Asociación Genética
/
República de Corea
/
Homeostasis del Telómero
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2015
Tipo del documento:
Artículo
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