Completion of Chronic Hepatitis C Virus Treatment in Interferon-Induced Major Depressive Disorder with Psychotic Features
Psychiatry Investigation
; : 381-383, 2011.
Article
en En
| WPRIM
| ID: wpr-183453
Biblioteca responsable:
WPRO
ABSTRACT
Interferon (IFN)-associated psychiatric disorders can be managed without interruption to hepatitis C virus (HCV) treatment. The limited number of cases in the literature reporting psychotic depression as an adverse drug reaction to IFN resulted in discontinuation of HCV therapy. The author reports a case of a 49 year-old man with chronic HCV genotype 1a treated with pegylated interferon-alpha and ribavirin developing major depressive disorder with psychotic features. The patient was successfully treated with both an antidepressant and antipsychotic for this suspected IFN-associated adverse drug effect while continuing 12 months of uninterrupted HCV treatment and subsequently achieving sustained hepatitis C virological response. Although IFN can cause distressing psychiatric disturbances, appropriate treatment with psychotropic agents and careful monitoring allows patients to be maintained on a full course of HCV treatment.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Trastornos Psicóticos
/
Ribavirina
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Interferones
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Interferón-alfa
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Hepatitis C
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Hepacivirus
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Hepatitis C Crónica
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Depresión
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Trastorno Depresivo Mayor
/
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
Límite:
Humans
Idioma:
En
Revista:
Psychiatry Investigation
Año:
2011
Tipo del documento:
Article