Is Systemic Inflammation Associated with Passive Smoke Exposure? A Population-Based Observational Study
Korean Circulation Journal
;
: 510-515, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-183599
ABSTRACT
BACKGROUND AND OBJECTIVES:
Passive smoking increases the risk of cardiovascular disease, but the factors responsible for this association remain largely unknown. We sought to determine whether passive smoke exposure is associated with systemic inflammation in a dose-dependent fashion, which is a known risk factor for cardiovascular events. SUBJECTS ANDMETHODS:
We analyzed the data of self-reported non-smokers, > or =40 years of age, who were from the Third National Health and Nutrition Examination Survey (n=6,595). We quantified the passive nicotine exposure by dividing the non-smokers into quartiles, as based on the serum cotinine values. We used multiple linear and logistic regression models to determine the independent relationship between serum cotinine and the levels of C-reactive protein, fibrinogen and leukocytes, and the platelet expression.RESULTS:
After adjustments were done for age, gender, body mass index and race, the participants in the highest serum cotinine quartile (quartile 4) had circulating platelet, fibrinogen and homocysteine levels that were 6,893/microliter higher (95% confidence interval [CI] 1,886 to 11,900/microliter, p=0.007), 8.74 mg/dL (95% CI 2.63 to 14.84 mg/dL, p=0.005) and 0.90 micromol/L (95% CI 0.36 to 1.43 (micromol/L, p=0.001), respectively, than in those in the lowest quartile of serum cotinine (quartile 1). There was a dose-dependent increase in the circulating fibrinogen, homocysteine and platelet levels across the quartiles of cotinine.CONCLUSION:
These findings indicate that even among nonsmokers, elevated serum cotinine is an independent risk factor for systemic inflammation. This suggests that passive smoke exposure promotes systemic inflammatory response in a dose-dependent fashion. These observations may explain why passive smoking is a risk factor for atherosclerosis and cardiovascular events.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Humo
/
Contaminación por Humo de Tabaco
/
Plaquetas
/
Proteína C-Reactiva
/
Fibrinógeno
/
Enfermedades Cardiovasculares
/
Índice de Masa Corporal
/
Modelos Logísticos
/
Encuestas Nutricionales
/
Epidemiología
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Circulation Journal
Año:
2006
Tipo del documento:
Artículo
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