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The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old / 소아과
Korean Journal of Pediatrics ; : 1185-1190, 2008.
Artículo en Coreano | WPRIM | ID: wpr-18367
ABSTRACT

PURPOSE:

This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea.

METHODS:

Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2006 to April 2007 . Diphtheria and tetanus anti-toxoid antibodies in sera were measured by ELISA just before vaccination and 4 weeks after vaccination to evaluate immunogenicity. Local and systemic adverse reactions observed for 4 weeks after vaccination to access reactogenicity.

RESULTS:

183 preadolescents were enrolled and mean age was 11.40+/-0.51 years old. All subjects achieved seroprotective diphtheria and tetanus anti-toxoid antibodies (titers > or =0.1 IU/mL) after Td booster vaccination. Among 183 vaccinees, 73.8% showed local adverse reactions and 37.2% systemic adverse reactions. Pain at injection site (66.1%) was the most common local reaction, and the most commonly shown systemic reaction was myalgia (17.5%). The adverse reactions were spontaneously relieved within three days after vaccination.

CONCLUSION:

Td vaccine in this study was high immunogenic and showed an acceptable tolerance in Korean preadolescents. Td booster vaccination at 11 -12 years old is the most effective method to increase compliance of the vaccination and to decrease the incidence of diphtheria and tetanus.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tétanos / Ensayo de Inmunoadsorción Enzimática / Incidencia / Inmunización Secundaria / Inmunización / Vacunación / Adaptabilidad / Vacunas contra Difteria, Tétanos y Tos Ferina Acelular / Vacuna contra Difteria y Tétanos / Difteria Tipo de estudio: Estudio de incidencia / Estudio pronóstico Límite: Anciano / Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Korean Journal of Pediatrics Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tétanos / Ensayo de Inmunoadsorción Enzimática / Incidencia / Inmunización Secundaria / Inmunización / Vacunación / Adaptabilidad / Vacunas contra Difteria, Tétanos y Tos Ferina Acelular / Vacuna contra Difteria y Tétanos / Difteria Tipo de estudio: Estudio de incidencia / Estudio pronóstico Límite: Anciano / Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Korean Journal of Pediatrics Año: 2008 Tipo del documento: Artículo