Significance of serum total bilirubin as a prognostic factor for hemophagocytic lymphohistiocytosis in childhood / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 75-81, 2014.
Artículo
en Coreano
| WPRIM
| ID: wpr-183724
ABSTRACT
BACKGROUND:
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease. Despite of proper treatment and improving treatment regimens, HLH patients still show a fatal prognosis. Therefore the evaluation of prognostic factor is important and there are many studies about hyperbilirubinemia as a prognostic factor in HLH. So we studied the prognostic value of hyperbilirubinemia in HLH children.METHODS:
A retrospective analysis was performed about 33 patients who were diagnosed with HLH at Pusan National University Hospital and Yangsan Pusan University Hospital between January 2000 to December 2012. We reviewed the clinical characteristics, laboratory findings, and results of treatment to identify hyperbilirubinemia as a prognostic factor in HLH patients.RESULTS:
The median age of patients at diagnosis was 32 months. Most of patients presented with fever, pale appearance, abdominal pain and jaundice. Forty-eight point five percentage of patients showed normal serum bilirubiln level ( or =2.0 mg/dL). In normal serum bilirubin group, 1 patient (6.3%) was relapsed and 1 patient (5.9%) was relapsed in hyperbilirubinemia group. In the hyperbilirubinemia group, the mortality was higher than the normal bilirubin group but, there was no statistical significance.CONCLUSION:
As a prognostic factor serum bilirubin at diagnosis in HLH patients, there was no significant correlation between hyperbilirubinemia and poor outcome. But, our study has a limitation that the number of patients is too small and almost showed good prognosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Bilirrubina
/
Fibrinógeno
/
Dolor Abdominal
/
Estudios Retrospectivos
/
Mortalidad
/
Diagnóstico
/
Linfohistiocitosis Hemofagocítica
/
Fiebre
/
Hiperbilirrubinemia
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Yeungnam University Journal of Medicine
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS