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The Effects of Galantamine Hydrobromide Treatment on Dehydroepiandrosterone Sulfate and Cortisol Levels in Patients with Chronic Fatigue Syndrome
Psychiatry Investigation ; : 204-210, 2009.
Artículo en Inglés | WPRIM | ID: wpr-183815
ABSTRACT

OBJECTIVE:

Mental fatigue, cognitive disorders, and sleep disturbances seen in chronic fatigue syndrome (CFS) may be attributed to cholinergic deficit. A functional deficiency of cholinergic neurotransmission may cause the hypothalamic-pituitary-adrenal axis hypoactivity seen in CFS. Therefore, we investigated the alterations in stress hormones such as cortisol and dehydroepiandrosterone sulfate (DHEAS) in CFS patients before and after 4-week administration of galantamine hydrobromide, a selective acetylcholinesterase inhibitor, and aimed to investigate whether there are any relationships between the probable hormonal changes and cholinergic treatment.

METHODS:

Basal levels of cortisol and DHEAS were measured in 29 untreated CFS patients who were diagnosed according to Centers for Disease Control (CDC) criteria and in 20 healthy controls. In the patient group, four weeks after 8 mg/d galantamine hydrobromide treatment, cortisol and DHEAS levels were measured again. After the treatment 22 patients who stayed in study were divided into two subgroups as responders and nonresponders according to the reduction in their Newcastle Research Group ME/CFS Score Card (NRG) scores.

RESULTS:

Important findings of this study are lower pre-and post-treatment cortisol levels and in all CFS patients compared to controls (F=4.129, p=0.049; F=4.803, p=0.035, respectively); higher basal DHEAS values and higher DHEAS/cortisol molar ratios which were normalized following four weeks' treatment with 8 mg/d galantamine hydrobromide in the treatment-respondent group (F=5.382, p=0.029; F=5.722, p=0.025, respectively).

CONCLUSION:

The findings of the decrease in basal DHEAS levels and DHEAS/cortisol molar ratios normalizing with galantamine treatment may give some support to the cholinergic deficit hypothesis in CFS.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Acetilcolinesterasa / Vértebra Cervical Axis / Hidrocortisona / Síndrome de Fatiga Crónica / Deshidroepiandrosterona / Transmisión Sináptica / Sulfato de Deshidroepiandrosterona / Fatiga Mental / Galantamina / Diente Molar Límite: Humanos Idioma: Inglés Revista: Psychiatry Investigation Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Acetilcolinesterasa / Vértebra Cervical Axis / Hidrocortisona / Síndrome de Fatiga Crónica / Deshidroepiandrosterona / Transmisión Sináptica / Sulfato de Deshidroepiandrosterona / Fatiga Mental / Galantamina / Diente Molar Límite: Humanos Idioma: Inglés Revista: Psychiatry Investigation Año: 2009 Tipo del documento: Artículo