Application of aptamers for assessment of vaccine efficacy
Clinical and Experimental Vaccine Research
; : 160-163, 2017.
Article
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| WPRIM
| ID: wpr-184068
Biblioteca responsable:
WPRO
ABSTRACT
Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy.
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WPRIM
Asunto principal:
Ensayo de Inmunoadsorción Enzimática
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Vacunas
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Vacunación
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Anticuerpos
Idioma:
En
Revista:
Clinical and Experimental Vaccine Research
Año:
2017
Tipo del documento:
Article