The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents
Clinical and Experimental Vaccine Research
;
: 83-94, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-184077
ABSTRACT
Due to the increased frequency of interspecies transmission of avian influenza viruses, studies designed to identify the molecular determinants that could lead to an expansion of the host range have been increased. A variety of mouse-based mammalian-adaptation studies of avian influenza viruses have provided insight into the genetic alterations of various avian influenza subtypes that may contribute to the generation of a pandemic virus. To date, the studies have focused on avian influenza subtypes H5, H6, H7, H9, and H10 which have recently caused human infection. Although mice cannot fully reflect the course of human infection with avian influenza, these mouse studies can be a useful method for investigating potential mammalian adaptive markers against newly emerging avian influenza viruses. In addition, due to the lack of appropriate vaccines against the diverse emerging influenza viruses, the generation of mouse-adapted lethal variants could contribute to the development of effective vaccines or therapeutic agents. Within this review, we will summarize studies that have demonstrated adaptations of avian influenza viruses that result in an altered pathogenicity in mice which may suggest the potential application of mouse-lethal strains in the development of influenza vaccines and/or therapeutics in preclinical studies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Orthomyxoviridae
/
Virus de la Influenza A
/
Virulencia
/
Pase Seriado
/
Vacunas contra la Influenza
/
Vacunas
/
Vacunación
/
Especificidad del Huésped
/
Pandemias
/
Gripe Aviar
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Clinical and Experimental Vaccine Research
Año:
2017
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS