Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases
Journal of Pathology and Translational Medicine
;
: 422-427, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-184095
ABSTRACT
Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Recurrencia
/
Mama
/
Proteínas S100
/
Estudios de Seguimiento
/
Carcinoma Intraductal no Infiltrante
/
Células Acinares
/
Enfermedad Fibroquística de la Mama
/
Neoplasias de la Mama Triple Negativas
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Pathology and Translational Medicine
Año:
2017
Tipo del documento:
Artículo
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