The Time Course Changes in Bone Metabolic Markers after Administering the Anti-Receptor Activator of Nuclear Factor-Kappa B Ligand Antibody and Drug Compliance among Patients with Osteoporosis
Asian Spine Journal
;
: 338-343, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-184118
ABSTRACT
STUDY DESIGN:
Retrospective study.PURPOSE:
We conducted a study to investigate the time course changes in bone metabolic markers after the administration of the anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody and to assess drug compliance among osteoporotic patients. OVERVIEW OF LITERATURE The anti-RANKL antibody is expected to provide an improvement in those with a bone metabolism disorder. However there are only a few clinical reports available on the effect of treatment.METHODS:
We included 40 post-menopausal osteoporotic patients who received the anti-RANKL antibody. To determine the time course changes in the bone metabolic markers, we measured the serum tartrate-resistant acid phosphatase 5b (TRACP 5b; a bone resorption marker) and the serum N-terminal propeptide of type 1 collagen (P1NP; a bone formation marker) levels prior to and 1 month after administrating the anti-RANKL antibody. To evaluable drug compliance, we assessed the dropout rate during treatment and at 6 months after treatment.RESULTS:
The average TRACP 5b level significantly decreased from 574.8 mU/dL before treatment to 153.2 mU/dL 1 month after treatment (p0.05). As for drug compliance, we did not have any dropouts during the treatment or after 6 months (dropout rate 0%).CONCLUSIONS:
Our study suggests that anti-RANKL antibody treatment suppresses bone resorption and maintains bone formation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteogénesis
/
Osteoporosis
/
Pacientes Desistentes del Tratamiento
/
Fosfatasa Ácida
/
Resorción Ósea
/
Estudios Retrospectivos
/
Adaptabilidad
/
Colágeno Tipo I
/
Ligando RANK
/
Metabolismo
Tipo de estudio:
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Asian Spine Journal
Año:
2015
Tipo del documento:
Artículo
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