Comparison of Gadolinium Polylysine and Gadopentetate in Contrast Enhanced MR Imaging of IVlyocardial Ischemia-Reperfusion in Cats
Journal of the Korean Radiological Society
;
: 59-65, 1995.
Artículo
en Coreano
| WPRIM
| ID: wpr-184319
ABSTRACT
PURPOSE:
To assess the signal enhancement by gadolinium-DTPA-polylysine (Gd-polylysine) as compared to gadopentetate (Gd-DTPA) in MR imaging of heart that have undergone ischemia-reperfusion, and to estimate the extent of myocardial damage covered bythe MR signal enhancement. MATERIALS ANDMETHODS:
A series of contrast enhanced cardiac MR images were obtained from 17 cats subjected to a 90 minutes of occlusion of the left anterior descending coronary artery (LAD) followed by a 90 minutes of raperfusion. Time courses of changes in the signal intensity (Sl) of the ischemic area were measu red in Gd-polylysine group (8 cats) and Gd- DTPA group (9 cats). The size of U R signal enhanced area was then compared to the sizes of infarction and the area at risk revealed byTTC histochemical staining.RESULTS:
Maximum Sis were obtained at 60 minutes and 30 minutes after injection of the contrast material, respectively for Gd-polylysine group and Gd-DTPA group. Signal enhancement was stronger and persistent for a longer period in Gd-polylysine group than in GD-DTPA group. Sizes of the enhanced area, the infarction, and the area at risk were about 30%, 15%, and 50% of the total left ventricle (LV) area; the difference between the groups was statistically insignificant.CONCLUSION:
Gd-polylysine can be used better for a blood pool marker than Gd-DTPA in MR imaging of myocardial ischemia, due to its strong and persistent signal enhancement. The MR signal enhanced area includes both the infarcted area and a portion of the area at risk.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polilisina
/
Imagen por Resonancia Magnética
/
Isquemia Miocárdica
/
Gadolinio DTPA
/
Vasos Coronarios
/
Ácido Pentético
/
Gadolinio
/
Corazón
/
Ventrículos Cardíacos
/
Infarto
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of the Korean Radiological Society
Año:
1995
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS