Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic beta-cell damage
Experimental & Molecular Medicine
;
: 136-139, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-18464
ABSTRACT
Cytokines produced by immune cells infiltrating pancreatic islets have been implicated as one of the important mediators of beta-cell destruction in insulin-dependent diabetes mellitus. In this study, the protective effects of epigallocatechin gallate (EGCG) on cytokine-induced beta-cell destruction were investigated. EGCG effectively protected IL-1beta and IFN-g-mediated cytotoxicity in insulinoma cell line (RINm5F). EGCG induced a significant reduction in IL-1b and IFN-gamma-induced nitric oxide (NO) production and reduced levels of the inducible form of NO synthase (iNOS) mRNA and protein levels on RINm5F cells. The molecular mechanism by which EGCG inhibited iNOS gene expression appeared to involve the inhibition of NF-kB activation. These findings revealed EGCG as a possible therapeutic agent for the prevention of diabetes mellitus progression.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Té
/
Catequina
/
Línea Celular
/
Supervivencia Celular
/
Western Blotting
/
Citocinas
/
Islotes Pancreáticos
/
Interferón gamma
/
Interleucina-1
/
Óxido Nítrico Sintasa
Límite:
Animales
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2003
Tipo del documento:
Artículo
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