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Frequency and Clinical Manifestations of Human Herpesvirus-6 Infection in Hematopoietic Stem Cell Transplant Recipients / 감염
Korean Journal of Infectious Diseases ; : 280-286, 2000.
Artículo en Coreano | WPRIM | ID: wpr-185005
ABSTRACT

BACKGROUND:

Human herpesvirus-6 (HHV-6) is recently known as a major pathogen associated with various diseases in hematopoietic stem cell transplant (HSCT) recipients. We prospectively evaluated the frequency and clinical manifestations of HHV-6 infection in HSCT recipient in a single HSCT center in Korea.

METHODS:

Serum and peripheral blood mononuclear cells (PBMC) were weekly obtained from 1 week before HSCT to 4 weeks after HSCT. Three months' and six months' samples were obtained in some cases. HHV-6 was detected by nested polymerase chain reaction.

RESULTS:

Two hundred and seventy-eight samples from 54 HSCT recipients were collected from February to November, 1999. HHV-6 was detected in 32 out of 54 recipients (59.3%) at least once during study period in their PBMC or serum. HHV-6 DNA positive rate of PBMC and serum samples were 38.1% and 4.3 % respectively. HHV-6 DNAemia (HHV-6 DNA positive in serum) was detected and peaked at 2 weeks after HSCT and continued to 4 weeks. HHV-6 DNA in peripheral blood was not associated with unexplained fever, acute graft-versus-host disease, engraftment delay, or cytomegalovirus infection in this study.

CONCLUSION:

Reactivation and development of DNAemia of HHV-6 certainly occurred after HSCT, but the clinical manifestations and association with other diseases were unclear in this study. The large-scaled, nation-wide detail studies about the prevalence and characteristics of HHV-6 in general population and patients of specific disease entities must be considered.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trasplante / ADN / Células Madre Hematopoyéticas / Reacción en Cadena de la Polimerasa / Prevalencia / Estudios Prospectivos / Herpesvirus Humano 6 / Infecciones por Citomegalovirus / Trasplante de Células Madre Hematopoyéticas / Fiebre Tipo de estudio: Estudio observacional / Estudio de prevalencia Límite: Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Korean Journal of Infectious Diseases Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trasplante / ADN / Células Madre Hematopoyéticas / Reacción en Cadena de la Polimerasa / Prevalencia / Estudios Prospectivos / Herpesvirus Humano 6 / Infecciones por Citomegalovirus / Trasplante de Células Madre Hematopoyéticas / Fiebre Tipo de estudio: Estudio observacional / Estudio de prevalencia Límite: Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Korean Journal of Infectious Diseases Año: 2000 Tipo del documento: Artículo