Genetic risk factors associated with respiratory distress syndrome / 소아과
Korean Journal of Pediatrics
;
: 157-163, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-185148
ABSTRACT
Respiratory distress syndrome (RDS) among preterm infants is typically due to a quantitative deficiency of pulmonary surfactant. Aside from the degree of prematurity, diverse environmental and genetic factors can affect the development of RDS. The variance of the risk of RDS in various races/ethnicities or monozygotic/dizygotic twins has suggested genetic influences on this disorder. So far, several specific mutations in genes encoding surfactant-associated molecules have confirmed this. Specific genetic variants contributing to the regulation of pulmonary development, its structure and function, or the inflammatory response could be candidate risk factors for the development of RDS. This review summarizes the background that suggests the genetic predisposition of RDS, the identified mutations, and candidate genetic polymorphisms of pulmonary surfactant proteins associated with RDS.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Gemelos
/
Surfactantes Pulmonares
/
Recien Nacido Prematuro
/
Factores de Riesgo
/
Predisposición Genética a la Enfermedad
/
Proteínas Asociadas a Surfactante Pulmonar
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
/
Recién Nacido
Idioma:
Inglés
Revista:
Korean Journal of Pediatrics
Año:
2014
Tipo del documento:
Artículo
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