Evaluation of the Release Behavior of the Dexamethasone Embedded in Polycarbonate Polyurethane Membranes: An In Vitro Study
Journal of the Korean Radiological Society
;
: 7-11, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-185310
ABSTRACT
PURPOSE:
To evaluate the release behavior of dexamethasone embedded in a polycarbonate polyurethane membrane. MATERIALS ANDMETHODS:
Both water-soluble and water-insoluble dexamethasone were tested, and the release behavior of five water-insoluble dexamethasone films of different thickness (78 to 211 micrometer) was also evaluated. The amount of Dexamethasone used was 10% of the total weight of the polyurethane film mass. Each film was placed in a centrifuge tube containing 25 ml of 0.1-M neutral phosphate buffer, and the tubes were placed in a shaking incubator to quantify the amount of drug released into the buffer, absorption spectroscopy (lambda max=242 nm) was employed.RESULTS:
In the test involving water-soluble dexamethasone, 60% of the drug was released during the first two hours of the study. Films containing water-insoluble Dexamethasone, on the other hand, released 40%, 60% and 75% of the dexamethasone in one, three and seven days, respectively. Both types of film maintained low-dose drug release for 28 days. When release behavior was compared between water-insoluble films of different thickness, thicker film showed less initial burst and more sustained release.CONCLUSION:
Dexamethasone release behavior varies according to drug solubility and membrane thickness, and may thus be conrolled.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Poliuretanos
/
Solubilidad
/
Análisis Espectral
/
Dexametasona
/
Absorción
/
Mano
/
Incubadoras
/
Membranas
Idioma:
Inglés
Revista:
Journal of the Korean Radiological Society
Año:
2003
Tipo del documento:
Artículo
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