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Influence of Lactate Dehydrogenase and Cyclosporine A Level on the Incidence of Acute Graft-versus-host Disease After Allogeneic Stem Cell Transplantation
Journal of Korean Medical Science ; : 555-560, 2009.
Artículo en Inglés | WPRIM | ID: wpr-185542
ABSTRACT
Previous reports have suggested that a high serum cyclosporine A (CsA) level could result in a lower incidence of acute-graft-versus-host disease (aGVHD). An elevated serum lactate dehydrogenase (LDH) level has been reported to be an adverse predictor of outcome in stem cell transplantation (SCT) for acute myeloid leukemia. In this study, we retrospectively analyzed the records of 24 patients who received allogeneic SCT from an HLA-matched sibling donor for acute and chronic myelogenous leukemia. Univariate analysis showed that two factors (the serum CsA level at the third week after SCT and the LDH level at the third week after SCT) were significantly associated with the incidence of aGVHD among several variables (age, sex, stem cell source, cell dose, C-reactive protein, absolute lymphocyte count, conditioning regimens, and time to engraftment). A higher serum level of CsA and lower serum LDH level at the third week after SCT were associated with a lower incidence of aGVHD (P=0.015, 0.030). In multivariate analysis, the serum CsA level (hazard ratio [HR], 0.12; 95% confidence interval [CI], 0.022-0.652, P=0.0014) and serum LDH level (HR, 6.59; 95% CI, 1.197-36.316, P=0.030) at the third week after SCT were found to be independent factors that were significantly associated with the development of aGVHD. We conclude that a high CsA level and low LDH level might predict a low cumulative incidence of aGVHD after allogeneic transplantation from a matched sibling donor.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trasplante Homólogo / Leucemia Mielógena Crónica BCR-ABL Positiva / Leucemia Mieloide Aguda / Enfermedad Aguda / Análisis Multivariante / Valor Predictivo de las Pruebas / Estudios Retrospectivos / Factores de Riesgo / Ciclosporina / Trasplante de Células Madre Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trasplante Homólogo / Leucemia Mielógena Crónica BCR-ABL Positiva / Leucemia Mieloide Aguda / Enfermedad Aguda / Análisis Multivariante / Valor Predictivo de las Pruebas / Estudios Retrospectivos / Factores de Riesgo / Ciclosporina / Trasplante de Células Madre Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2009 Tipo del documento: Artículo