Effects of decreased cerebral perfusion pressure on cerebral hemodynamics, brain cell membrane function and energy metabolism during the early phase of experimental Escherichia coli meningitis in the newborn piglet
Journal of Korean Medical Science
;
: 203-210, 2000.
Artículo
en Inglés
| WPRIM
| ID: wpr-18569
ABSTRACT
In this study, we tested the hypothesis that decreased cerebral perfusion pressure (CPP) induces cerebral ischemia and worsen brain damage in neonatal bacterial meningitis. Meningitis was induced by intracisternal injection of 10(9) colony forming units of Escherichia coli in 21 newborn piglets. Although CPP decreased significantly at 8 hr after bacterial inoculation, deduced hemoglobin (HbD), measured as an index of changes in cerebral blood flow by near infrared spectroscopy, did not decrease significantly. In correlation analyses, CPP showed significant positive correlation with brain ATP and inverse correlation with brain lactate levels. CPP also correlated positively with HbD and oxidized cytochrome aa3 (Cyt aa3) by near infrared spectroscopy. However, CPP did not show significant correlation with cerebral cortical cell membrane Na+,K+-ATPase activity, nor with levels of lipid peroxidation products. In summary, decreased CPP observed in this study failed to induce cerebral ischemia and further brain injury, indicating that cerebrovascular autoregulation is intact during the early phase of experimental neonatal bacterial meningitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Porcinos
/
Glucemia
/
Peroxidación de Lípido
/
Presión Intracraneal
/
Membrana Celular
/
Corteza Cerebral
/
Circulación Cerebrovascular
/
Meningitis Bacterianas
/
ATPasa Intercambiadora de Sodio-Potasio
/
Ácido Láctico
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2000
Tipo del documento:
Artículo
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