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Granulocyte Colony-Stimulating Factor for Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study of Iranian Patients
Journal of Clinical Neurology ; : 164-171, 2015.
Artículo en Inglés | WPRIM | ID: wpr-186077
ABSTRACT
BACKGROUND AND

PURPOSE:

The aim of this study was to determine the efficacy and tolerability of granulocyte colony-stimulating factor (G-CSF) in subjects with amyotrophic lateral sclerosis (ALS).

METHODS:

Forty subjects with ALS were randomly assigned to two groups, which received either subcutaneous G-CSF (5 microg/kg/q12h) or placebo for 5 days. The subjects were then followed up for 3 months using the ALS Functional Rating Scale-Revised (ALSFRS-R), manual muscle testing, ALS Assessment Questionnaire-40, and nerve conduction studies. CD34+/CD133+ cell count and monocyte chemoattractant protein-1 (MCP-1) levels were evaluated at baseline.

RESULTS:

The rate of disease progression did not differ significantly between the two groups. The reduction in ALSFRS-R scores was greater in female subjects in the G-CSF group than in their counterparts in the placebo group. There was a trend toward a positive correlation between baseline CSF MCP-1 levels and the change in ALSFRS-R scores in both groups (Spearman's rho=0.370, p=0.070).

CONCLUSIONS:

With the protocol implemented in this study, G-CSF is not a promising option for the treatment of ALS. Furthermore, it may accelerate disease progression in females.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recuento de Células / Factor Estimulante de Colonias de Granulocitos / Progresión de la Enfermedad / Quimiocina CCL2 / Esclerosis Amiotrófica Lateral / Conducción Nerviosa Tipo de estudio: Ensayo Clínico Controlado / Guía de Práctica Clínica Límite: Femenino / Humanos Idioma: Inglés Revista: Journal of Clinical Neurology Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recuento de Células / Factor Estimulante de Colonias de Granulocitos / Progresión de la Enfermedad / Quimiocina CCL2 / Esclerosis Amiotrófica Lateral / Conducción Nerviosa Tipo de estudio: Ensayo Clínico Controlado / Guía de Práctica Clínica Límite: Femenino / Humanos Idioma: Inglés Revista: Journal of Clinical Neurology Año: 2015 Tipo del documento: Artículo