Generation of transgenic corn-derived Actinobacillus pleuropneumoniae ApxIIA fused with the cholera toxin B subunit as a vaccine candidate
Journal of Veterinary Science
;
: 401-403, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-186140
ABSTRACT
Corn, one of the most important forage crops worldwide, has proven to be a useful expression vehicle due to the availability of established transformation procedures for this well-studied plant. The exotoxin Apx, a major virulence factor, is recognized as a common antigen of Actinobacillus (A.) pleuropneumoniae, the causative agent of porcine pleuropneumonia. In this study, a cholera toxin B (CTB)-ApxIIA#5 fusion protein and full-size ApxIIA expressed in corn seed, as a subunit vaccine candidate, were observed to induce Apx-specific immune responses in mice. These results suggest that transgenic corn-derived ApxIIA and CTB-ApxIIA#5 proteins are potential vaccine candidates against A. pleuropneumoniae infection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas Bacterianas
/
Infecciones por Actinobacillus
/
Vacunas Bacterianas
/
Toxina del Cólera
/
Inmunización Secundaria
/
Plantas Modificadas Genéticamente
/
Actinobacillus pleuropneumoniae
/
Zea mays
/
Proteínas Hemolisinas
/
Ratones Endogámicos ICR
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2011
Tipo del documento:
Artículo
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