New Perspectives on Diabetic Vascular Complications: The Loss of Endogenous Protective Factors Induced by Hyperglycemia
Diabetes & Metabolism Journal
;
: 8-11, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-186259
ABSTRACT
Diabetic vascular complications are among the leading causes of morbidity and mortality in diabetic patients. In the past, many studies have focused on the mechanisms of hyperglycemia-induced chronic vascular complications via the formation of toxic metabolites such as oxidative stress, advanced glycosylated end products, persistent activation of protein kinase C, and increased sorbitol concentrations. However, vascular complications result from imbalances caused by increases in systemic toxic metabolites, such as those that occur under conditions of hyperglycemia and dyslipidemia, and by reductions in endogenous protective factors such as insulin, vascular endothelial growth factor, and platelet derived growth factor. This review outlines some of the evidence supporting the importance of enhancing endogenous regenerative factors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sorbitol
/
Proteína Quinasa C
/
Factor de Crecimiento Derivado de Plaquetas
/
Estrés Oxidativo
/
Factor A de Crecimiento Endotelial Vascular
/
Angiopatías Diabéticas
/
Dislipidemias
/
Hiperglucemia
/
Insulina
Límite:
Humanos
Idioma:
Inglés
Revista:
Diabetes & Metabolism Journal
Año:
2011
Tipo del documento:
Artículo
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