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Transcriptional mutagenesis by 8-oxodG in alpha-synuclein aggregation and the pathogenesis of Parkinson's disease
Experimental & Molecular Medicine ; : e179-2015.
Artículo en Inglés | WPRIM | ID: wpr-186436
ABSTRACT
Parkinson's disease (PD) is an age-related progressive neurodegenerative disease associated with selective loss of dopaminergic neurons. The characteristic hallmark of the disease is intracytoplasmic proteinacious inclusion bodies called Lewy bodies, primarily consisting of a presynaptic protein alpha-synuclein. Oxidative stress-mediated damage to macromolecules have been shown to occur frequently in PD. Oxidative damage to DNA in the form of oxidized guanine (8-oxodG) accumulates in both the mitochondrial and nuclear DNA of dopaminergic neurons of the substantia nigra in PD. 8-oxodG-mediated transcriptional mutagenesis has been shown to have the potential to alter phenotype of cells through production of mutant pool of proteins. This review comprehensively summarizes the role of oxidative stress-mediated damage incurred during neurodegeneration, and highlights the scope of transcriptional mutagenesis event in leading to alpha-synuclein aggregation as seen in PD.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Transcripción Genética / Sustancia Negra / Datos de Secuencia Molecular / Mutagénesis / Secuencia de Aminoácidos / Estrés Oxidativo / Desoxiguanosina / Alfa-Sinucleína / Agregación Patológica de Proteínas Tipo de estudio: Estudio de etiología Límite: Animales / Humanos Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Transcripción Genética / Sustancia Negra / Datos de Secuencia Molecular / Mutagénesis / Secuencia de Aminoácidos / Estrés Oxidativo / Desoxiguanosina / Alfa-Sinucleína / Agregación Patológica de Proteínas Tipo de estudio: Estudio de etiología Límite: Animales / Humanos Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2015 Tipo del documento: Artículo