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The Effects of Dexmedetomidine on Hemodynamics and Plasma Catecholamine Concentrations during Coronary Artery Bypass Graft Surgery / 대한마취과학회지
Korean Journal of Anesthesiology ; : 198-204, 2004.
Artículo en Coreano | WPRIM | ID: wpr-187334
ABSTRACT

BACKGROUND:

Alpha-2 adrenergic agonists decrease the sympathetic tones of hemodynamic and endocrine responses to surgical stimuli. The goal of this study was to evaluate the hemodynamic and endocrinologic effects of intraoperatively administered dexmedetomidine, a highly selective alpha-2 adrenergic agonist, in patients undergoing coronary artery bypass graft surgery.

METHODS:

Fifty coronary artery bypass graft patients, in a double-blind, randomized manner, received a continuous infusion of normal saline placebo or dexmedetomidine, 10 ng/kg/min for 1 hr from 5 minutes after sternotomy. All patients received standardized anesthesia. Plasma catecholamine was measured at 5 minutes after sternotomy (T1), 30 minutes after drug infusion (T2), and 30 minutes after drug cessation (T3). Heart rate, blood pressure, pulmonary artery pressure and cardiac output were monitored.

RESULTS:

Compared with the placebo group, plasma norepinephrine concentrations decreased in the dexmedetomidine group Dexmedetomidine attenuated increased blood pressure on surgical stimuli and induced more hypotension.

CONCLUSIONS:

The intraoperative infusion of dexmedetomidine to patients undergoing coronary artery bypass graft surgery reduced sympathetic tone and attenuated hemodynamic responses to surgical stimuli.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Arteria Pulmonar / Presión Sanguínea / Gasto Cardíaco / Norepinefrina / Puente de Arteria Coronaria / Agonistas Adrenérgicos / Vasos Coronarios / Trasplantes / Dexmedetomidina Tipo de estudio: Ensayo Clínico Controlado Límite: Humanos Idioma: Coreano Revista: Korean Journal of Anesthesiology Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Arteria Pulmonar / Presión Sanguínea / Gasto Cardíaco / Norepinefrina / Puente de Arteria Coronaria / Agonistas Adrenérgicos / Vasos Coronarios / Trasplantes / Dexmedetomidina Tipo de estudio: Ensayo Clínico Controlado Límite: Humanos Idioma: Coreano Revista: Korean Journal of Anesthesiology Año: 2004 Tipo del documento: Artículo