Detection of chromosome aberrations in interphase nuclei using fluorescence in situ hybridization technique
Journal of Korean Medical Science
;
: 257-261, 1993.
Artículo
en Inglés
| WPRIM
| ID: wpr-18734
ABSTRACT
We report here several experiences of interphase cytogenetics, using fluorescence in situ hybridization (FISH) technique, for the detection of chromosome aberrations. FISH, using alpha satellite specific probes of 18, X, Y chromosomes, was done in interphase nuclei from peripheral blood of patients with Edwards' syndrome, Klinefelter's syndrome and Turner's syndrome with healthy male and female controls, respectively. The distributions of fluorescent signals in 100 interphase nuclei were well correlated with metaphase findings. Nowadays FISH plays an increasingly important role in a variety of research areas, including cytogenetics, prenatal diagnosis, tumor biology, gene amplification and gene mapping.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Núcleo Celular
/
Aberraciones Cromosómicas
/
Bandeo Cromosómico
/
Hibridación Fluorescente in Situ
/
Interfase
Tipo de estudio:
Estudio diagnóstico
Límite:
Adolescente
/
Adulto
/
Niño
/
Femenino
/
Humanos
/
Masculino
/
Recién Nacido
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1993
Tipo del documento:
Artículo
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