Induction of c-Jun mRNA without changes of estrogen and progesterone receptor expression in myometrium during human labor
Journal of Korean Medical Science
;
: 552-558, 1999.
Artículo
en Inglés
| WPRIM
| ID: wpr-187362
ABSTRACT
To elucidate the endocrine mechanism of human parturition, the expression of c-Jun and c-Fos mRNA were examined in relation to estrogen receptor (ER) and progesterone receptor (PR) in human myometrium. c-Jun mRNA was detected in all myometrial tissues (n=5) during labor but not before labor (n=5) and in oxytocin-resistant postterm pregnancy (n=3). c-Fos mRNA was detected in only one myometrial tissue from a woman in labor. The distribution and intensity of immunostaining for ER and PR were semiquantitatively scored. During the late pregnancies, no significant difference was seen in the receptor scores for myometrial ER and PR between the patients who experienced labor and those who did not. Receptor scores for ER and PR were significantly lower in postterm pregnancy than in late pregnancy, regardless of the labor status. These data suggest that there are no changes in ER and PR in human myometrium during parturition. On the other hand, postterm pregnancy is associated with low ER and PR. c-Jun, induced during labor without changes in ER and PR, may play a role as a signaling mechanism in human myometrium.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Valores de Referencia
/
Trabajo de Parto
/
ARN Mensajero
/
Inmunohistoquímica
/
Receptores de Progesterona
/
Receptores de Estrógenos
/
Northern Blotting
/
Genes jun
/
Miometrio
Límite:
Adulto
/
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1999
Tipo del documento:
Artículo
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